The Nephroprotective Effects of Moringa Oleifera Extract against Contrast Induced Nephrotoxicity

Objectives: The present research has been conducted to assess the Nephroprotective effects of Moringa Oleifera Extract against contrast -induced nephrotoxicity in male rabbits.
 Study Design: Experimental design
 Place and Duration Study: it was carried out Faculty Pharmacy/University Kufa, Iraq/Al-Najaf Town .The study began at October 2020 end March 2021.
 Methodology: Twenty one adult (male rabbits) weighing range(1.2-1.5kg). Rabbits are divided a random manner into three equal groups each group including seven rabbits. Group1:control administered DW, Group2:has treated with Iodide contrast(2.5mg/kg) (370mg/ml),group 3: dosed alcoholic extracts 250 mg/kg (2.5mg/kg).By accounting data on MDA levels ,Glutathione level features kidney histopathology. All efforts have made reduce suffering animals prior throughout experiment sampling.
 Results: extract 250mg/kg body weight doses orally considerably protected induced toxicity kidneys rabbits through increment GSH reduces MDA. In Histological data, activities also protect damage kidney, which is by that represented de-generation some tubules atrophy glomerular, glomerular tuft congestion expanded Bowman’s Space.
 Conclusions: This proposed Moringa’s results enhancement defense status oxidative stress renal toxicity.(Moringa effect induce Nephrotoxicity).